Each session is usually around 45 minutes.

The average number of sessions required for optimal results are 2-3, with a minimum of 15 days inbetween sessions. This treatment can be applied in combination with devices or topically at the discretion of the doctor.

Treatment with recombinant enzymes is safe however there are some potential expected effects expected after treatment which include:

• Pain in the injection site 
• Itching or stinging 
• General discomfort 
• Local inflammation and/or erythema.

These effects usually last between 4-72 hours. 

• Reduce carbohydrate intake and avoid excess of fats 
• Drink plenty of water 
• Avoid intense exercise for the first 48 hours 
• Do not apply cold compresses or ice 
• Avoid excessive heat, saunas, sun beds and swimming pools for one week 
• Apply photo protector (+50 SPF)
• Wait at least 15 days before starting another therapy in the area of treatment (fillers, botox, threads, etc).

Treatment with recombinant enzymes is best avoided in the following circumstances:

• Pregnancy or lactation 
• Active dermopathy in the area of application
• Allergy to hyaluronic acid or to the enzymes present in the product. 
• Active autoimmune or inflammatory disease. 
• Treatment with corticosteroids, immunosuppressants or immunomodulators. 
• Unresolved allergic reaction 
• Local or systemic infection
• Decompensated metabolic disease. 
• Active cancer during treatment (or in the last 6 months) 
• Severe atopic dermatitis or asthma 
• Vascular or coagulation problems. Anticoagulant treatment in progress 
• Has been vaccinated in the last 15 days